Detail
| LncRNA Name | lincRNA-p21 |
| Synonyms | TP53COR1, linc-p21, lincRNA-p21 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, RIP, ISH, MTT assay etc. |
| Sample | cell lines (HCT-116, MCF-7) |
| Expression Pattern | up-regulated |
| Function Description | We found that Linc-RoR was highly expressed in tumor specimens compared to normal tissue. Linc-RoR knockout (KO) suppresses cell proliferation and tumor growth. In particular, Linc-RoR KO causes a significant decrease in c-Myc whereas re-expression of Linc-RoR in the KO cells restores the level of c-Myc. As a result, Linc-RoR may contribute to the increased stability of c-Myc mRNA. Although hnRNP I and AUF1 can interact with many RNA species and regulate their functions, with involvement of Linc-RoR they would be able to selectively regulate mRNA stability of specific genes such as c-Myc. |
| Pubmed ID | 26656491 |
| Year | 2016 |
| Title | Linc-RoR promotes c-Myc expression through hnRNP I and AUF1. |
| External Links |
| Links for lincRNA-p21 | GenBank HGNC lncrnadb Noncode |
| Links for colon cancer | Omim Cosmic |
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