Detail
| LncRNA Name | lincRNA-p21 |
| Synonyms | TP53COR1, linc-p21, lincRNA-p21 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR etc. |
| Sample | cell lines (wt MEFs, NIH/3T3 MEFs etc.) |
| Expression Pattern | down-regulated |
| Function Description | Indeed, lincRNA-p21 overexpression in a lung cancer cell line harboring a KRAS mutation (referred to as LKR) and in NIH/3T3 MEFs caused a significant decrease in cell viability. This decrease in viability was due to increased apoptosis in response to DNA damage and not to an effect in cell cycle regulation. |
| Pubmed ID | 20673990 |
| Year | 2010 |
| Title | A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. |
| External Links |
| Links for lincRNA-p21 | GenBank HGNC lncrnadb Noncode |
| Links for lung cancer | Omim Cosmic |
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