Detail
| LncRNA Name | lincRNA-p21 |
| Synonyms | TP53COR1, linc-p21, lincRNA-p21 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | GC tissues, cell lines (MGC-803, MKN-45, BGC-823, MKN-28, SGC-7901, GES-1) |
| Expression Pattern | down-regulated |
| Function Description | p21 was significantly reduced in gastric cancer tissues (p<0.001) compared with that in normal tissues and this lower level of lincRNA-p21 was significantly correlated with higher invasion depth grade (p=0.024), more distant metastasis (p=0.009) and advanced TNM stage (p=0.011).The high incidence rate and relative low survival rate makes gastric cancer a significant threat to human health. |
| Pubmed ID | 28969031 |
| Year | 2017 |
| Title | Down regulation of lincRNA-p21 contributes to gastric cancer development through Hippo-independent activation of YAP. |
| External Links |
| Links for lincRNA-p21 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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