Detail
| LncRNA Name | lincRNA-p21 |
| Synonyms | TP53COR1, linc-p21, lincRNA-p21 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Northern blot, Luciferase reporter assay, Cell viability assay etc. |
| Sample | cell lines (SW480, SW620, HCT116, LoVo, HT29 and RKO) |
| Expression Pattern | down-regulated |
| Function Description | We measured the expression level of lincRNA-p21 and found that it was significantly downregulated in CRC specimens, as compared to the paired non-cancerous colorectal epithelia from 24 patients. mportantly, the expression levels of lincRNA-p21 were significantly lower in ALDH+ CSCs than ALDH- non-CSCs from several CRC cell lines as well as primary tumor cells CRC 1 |
| Pubmed ID | 26497997 |
| Year | 2015 |
| Title | miRNA-regulated delivery of lincRNA-p21 suppresses β-catenin signaling and tumorigenicity of colorectal cancer stem cells |
| External Links |
| Links for lincRNA-p21 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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