Detail
| LncRNA Name | lincRNA-p21 |
| Synonyms | TP53COR1, linc-p21, lincRNA-p21 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | prostate cancer tissues, cell lines (LNCaP, DU145 and PC3) |
| Expression Pattern | down-regulated |
| Function Description | LincRNA-p21 was found to be down-regulated in human prostate cancer, and low levels of lincRNA-p21 correlated with high disease stage and prediction of poor survival. We further showed that lincRNA-p21 inhibited prostate cancer cell proliferation and colony formation in vitro and reduced rate of prostate cancer cell population growth in vivo. Study of mechanisms involved revealed that lincRNA-p21 promoted apoptosis and induced expression of p53 downstream genes by regulating p53 binding to their promoters. |
| Pubmed ID | 27976428 |
| Year | 2017 |
| Title | Long intragenic non-coding RNA lincRNA-p21 suppresses development of human prostate cancer. |
| External Links |
| Links for lincRNA-p21 | GenBank HGNC lncrnadb Noncode |
| Links for prostate cancer | Omim Cosmic |
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