Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name lincRNA-p21
   Synonyms TP53COR1, linc-p21, lincRNA-p21
   Region NA    Sequence
   Ensembl NA
   RefSeq NA
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name colorectal cancer
   ICD-0-3 C19.9  
   Methods qPCR etc.
   Sample CRC tissues, cell lines (HCT-116 (p53t/t), HCT-116(p53-/-) etc.)
   Expression Pattern down-regulated
   Function Description

We discovered that the expression level of lincRNA-p21 was increased by elevated wild-type p53 induced by nutlin-3 in HCT-116 colon cancer cells. The expression level of lincRNA-p21 was significantly lower in CRC tumor tissue when compared with the paired normal tissue from the same patient.

   Pubmed ID 24012455
   Year 2013
   Title Clinical significance of long intergenic noncoding RNA-p21 in colorectal cancer.
   External Links
   Links for  lincRNA-p21 GenBank       HGNC       lncrnadb       Noncode
   Links for  colorectal cancer Omim       Cosmic

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