Detail
| LncRNA Name | linc-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 Sequence |
| Ensembl | ENSG00000258609 |
| RefSeq | NR_048536 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✔ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | endometrial cancer |
| ICD-0-3 | M8380/3 |
| Methods | qPCR, RNAi, Flow cytometry assay, FISH etc. |
| Sample | endometrial carcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | We began by assessing the expression of linc-RoR in ECSC growing under tumorsphere conditions and differentiated conditions (removal of bFGF). In qRT-PCR analyses, a marked reduction of linc-RoR and core TFs was observed in all differentiated tumorspheres. This finding suggested that linc-RoR expression was positively correlated with levels of undifferentiated tumorspheres. The effects of miR-145 could be eliminated after increasing the expression of linc-RoR in ETs or mutated targeted sequences in linc-RoR. |
| Pubmed ID | 24589415 |
| Year | 2014 |
| Title | Linc-RNA-RoR acts as a sponge against mediation of the differentiation of endometrial cancer stem cells by microRNA-145. |
| External Links |
| Links for linc-ROR | GenBank HGNC lncrnadb Noncode |
| Links for endometrial cancer | Omim Cosmic |
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