Detail
| LncRNA Name | linc-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 Sequence |
| Ensembl | ENSG00000258609 |
| RefSeq | NR_048536 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR etc. |
| Sample | Triple-negative breast cancer tissues, cell line (HEK293T, MCF-10A, MCF-7, BT474, MDA-MB-453 and MDA-MB-231) |
| Expression Pattern | down-regulated |
| Function Description | lincRNA-ROR was upregulated in TNBC cell lines and tissue samples.The aberrant expression of lincRNA-ROR was shown to increase invasion and metastasis in MDA-MB-231 and loss of function by siRNA reverse these process.Furthermore, lincRNA-ROR functions as a competing endogenous RNAs (ceRNA) which sponges miR-145 and therefore upregulate the expression of Mucin1 (MUC1).Studies showed that downregulated SPRY4-IT1 could facilitate bladder cancer cell apoptosis via acting as a ceRNA for miR-101-3p. |
| Pubmed ID | 29673594 |
| Year | 2018 |
| Title | LincRNA-RoR/miR-145 promote invasion and metastasis in triple-negative breast cancer via targeting MUC1. |
| External Links |
| Links for linc-ROR | GenBank HGNC lncrnadb Noncode |
| Links for triple negative breast cancer | Omim Cosmic |
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