Detail
| LncRNA Name | linc-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 Sequence |
| Ensembl | ENSG00000258609 |
| RefSeq | NR_048536 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | GBC tissues, cell lines (SGC-996, GBC-SD, Noz) |
| Expression Pattern | up-regulated |
| Function Description | We found that LncRNA-ROR expression level was upregulated in gallbladder cancer tissues and was significantly associated with tumor sizes and lymph node metastasis. High expression of LncRNA-ROR was significantly associated with poor prognosis in gallbladder cancer patients. Moreover, knockdown of LncRNA-ROR inhibited cell proliferation, migration, and invasion. The epithelial-mesenchymal transition (EMT) phenotype induced by TGF-B1 was reversed after LncRNA-ROR knocking down in SGC-996 and Noz cells. |
| Pubmed ID | 27449039 |
| Year | 2016 |
| Title | Overexpression of LncRNA-ROR predicts a poor outcome in gallbladder cancer patients and promotes the tumor cells proliferation, migration, and invasion. |
| External Links |
| Links for linc-ROR | GenBank HGNC lncrnadb Noncode |
| Links for gallbladder cancer | Omim Cosmic |
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