Detail
| LncRNA Name | linc-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 Sequence |
| Ensembl | ENSG00000258609 |
| RefSeq | NR_048536 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi etc. |
| Sample | cell lines (AGS1, MGC803, SGC7901, and MKN48), gastric adenocarcinomas tissues |
| Expression Pattern | down-regulated |
| Function Description | LINCROR could sponge the miR-148a, miR-145 and miR-21 and can act as ceRNA modulating the miRNA-mediated post-transcriptional regulation of EGFR, KLF4, DNMT1 and AGO4 . The downregulation of LINCROR when its target miR-145 abundantly expressed.In addition, we observed the expression level LINCROR directly correlated with the overexpression of the miR-145. This relationship has been already reported in colon cancer and shown to be involved in overall survival. Our results suggest that reduced LINCROR/high miR-145 might be associated with better prognosis. LINCROR is an active member associated with reprogramming and stemness-related transcription factors. Downregulation of LINCROR by miR-145 might impair the cancer stemness by deregulation of another transcription factor KLF4 . |
| Pubmed ID | 29719612 |
| Year | 2018 |
| Title | Comprehensive analysis of aberrantly expressed lncRNAs and construction of ceRNA network in gastric cancer. |
| External Links |
| Links for linc-ROR | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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