Detail
| LncRNA Name | linc-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 Sequence |
| Ensembl | ENSG00000258609 |
| RefSeq | NR_048536 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot, Luciferase report assay etc. |
| Sample | HCC tissues, cell lines (HH, HCCLM3, MHCC97-H, HepG2 and SMMC-7721) |
| Expression Pattern | up-regulated |
| Function Description | linc-ROR was upregulated in HCC tissues and high linc-ROR expression level predicted poor prognosis.ROR was upregulated in HCC tissues and high linc-ROR expression level predicted poor prognosis. ROR and ZEB2 interact with miR-145 by functioning as competing endogenous RNAs (ceRNAs).The disease-free survival (DFS) and over survival (OS) curves were plotted using the Kaplan-Meier method. |
| Pubmed ID | 28680141 |
| Year | 2017 |
| Title | The lincRNA-ROR/miR-145 axis promotes invasion and metastasis in hepatocellular carcinoma via induction of epithelial-mesenchymal transition by targeting ZEB2. |
| External Links |
| Links for linc-ROR | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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