Detail
| LncRNA Name | linc-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 Sequence |
| Ensembl | ENSG00000258609 |
| RefSeq | NR_048536 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, MTT assay etc. |
| Sample | CRC tissues, cell lines (M5, DLD1, HCT116, SW480, SW620, and HT29) |
| Expression Pattern | up-regulated |
| Function Description | The expression level of lncRNA-ROR was elevated in CRC tissues when compared to adjacent tissues. lncRNA-ROR knockdown significantly suppressed cell proliferation and viability. Decreased lncRNA-ROR expression enhanced cell apoptosis and triggered cell cycle arrest in G0/G1 phase, while elevated lncRNA-ROR expression presented the opposite effect. Protein levels of p53 and p53 target genes were affected by lncRNA-ROR in vitro, and downregulation of lncRNA-ROR impeded tumorigenesis in vivo. |
| Pubmed ID | 28216611 |
| Year | 2017 |
| Title | Long Non-Coding RNA Reprogramming (ROR) Promotes Cell Proliferation in Colorectal Cancer via Affecting P53. |
| External Links |
| Links for linc-ROR | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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