Detail
| LncRNA Name | linc-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 Sequence |
| Ensembl | ENSG00000258609 |
| RefSeq | NR_048536 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (MCF10A, MCF7, MDA-MB-231, HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | Compared with immortalized MCF10A breast epithelial cells, lncRNA-ROR was highly expressed in MCF7 (nonresistant) and MDA-MB-231 (drug-resistant) cell lines. The lncRNA-ROR level was strongly elevated in the MDA-MB-231 cell line as compared to the MCF7 cell line, indicating that lncRNA-ROR can be involved in the development of breast cancer. |
| Pubmed ID | 28063065 |
| Year | 2017 |
| Title | Effects of long noncoding RNA-ROR on tamoxifen resistance of breast cancer cells by regulating microRNA-205. |
| External Links |
| Links for linc-ROR | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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