Detail
| LncRNA Name | linc-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 Sequence |
| Ensembl | ENSG00000258609 |
| RefSeq | NR_048536 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | microarray, qPCR, Western blot etc. |
| Sample | breast cancer tissues, cell lines (HEK293T, MCF-7, HS578T, MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | lincRNA-RoR was significant upregulated in DCIS and IDC tumor tissues, showing the highest expression in invasive tumor tissues. Overexpression of the long non-coding RNA, lincRNA-RoR, functions as a competitive endogenous RNA sponge in TNBC. Interestingly, lincRNA-RoR is dramatically upregulated in TNBC and in metastatic disease and knockdown restores miR-145 expression. |
| Pubmed ID | 25253741 |
| Year | 2014 |
| Title | lincRNA-RoR and miR-145 Regulate Invasion in Triple-negative Breast Cancer via Targeting ARF6. |
| External Links |
| Links for linc-ROR | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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