Detail
| LncRNA Name | linc-UFC1 |
| Synonyms | UFC1, HSPC155 |
| Region | GRCh38_1:161152776-161158856 Sequence |
| Ensembl | ENSG00000143222 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | microarray, qPCR, in vitro knockdown etc. |
| Sample | HCC tissues, cell lines (BEL-7402, SK-Hep1, Huh7, MHCC-97H) |
| Expression Pattern | up-regulated |
| Function Description | Levels of the lincRNA-UFC1 were increased in HCC tissues compared with controls, and associated with tumor size, Barcelona Clinic Liver Cancer stage, and patient outcomes. Transgenic expression of the lincRNA-UFC1 in HCC cells promoted their proliferation and cell-cycle progression and inhibited apoptosis, whereas short hairpin RNA knockdown of lincRNA-UFC1 had opposite effetcs.The lincRNA-UFC1 interacted directly with the messenger RNA (mRNA) stabilizing protein HuR (encoded by ELAVL1) to increase levels of B-catenin mRNA (encoded by CTNNB1) and protein. In contrast, there was a negative correlation between levels of microRNA 34a and lincRNA-UFC1 in HCC tissues microRNA 34a reduced the stability of lincRNA-UFC1. |
| Pubmed ID | 25449213 |
| Year | 2014 |
| Title | The Long Intergenic Noncoding RNA UFC1, A Target of MicroRNA 34a, Interacts With the mRNA Stabilizing Protein HuR to Increase Levels of B-Catenin in HCC Cells. |
| External Links |
| Links for linc-UFC1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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