Detail
| LncRNA Name | LINK-A |
| Synonyms | LINC01139, LINK-A, LINKA, TCONS_00000027 |
| Region | GRCh38_1:238480384-238486023 Sequence |
| Ensembl | ENSG00000215808 |
| RefSeq | NR_015407 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Cell transfection, Fluorescence quenching assay, Lipid-RNA pulldown assay etc. |
| Sample | TNBC tissues, cell lines (MDA-MB-231, MDA-MB-468, MCF-10A) |
| Expression Pattern | differential expression |
| Function Description | LINK-A directly interacts with the AKT pleckstrin homology domain and PIP3 at the single-nucleotide level, facilitating AKT-PIP3 interaction and consequent enzymatic activation. LINK-A-dependent AKT hyperactivation leads to tumorigenesis and resistance to AKT inhibitors. Genomic deletions of the LINK-A PIP3-binding motif dramatically sensitized breast cancer cells to AKT inhibitors. |
| Pubmed ID | 28218907 |
| Year | 2017 |
| Title | The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors. |
| External Links |
| Links for LINK-A | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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