Detail
| LncRNA Name | LINP1 |
| Synonyms | NA |
| Region | GRCh38_10:6737382-6739026 Sequence |
| Ensembl | ENSG00000223784 |
| RefSeq | NR_138480 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot |
| Sample | breast cancer tissues, Human breast cancer cells (MDA-MB-231, MDA-MB-468 and MCF7) |
| Expression Pattern | up-regulated |
| Function Description | LINP1 knockdown mitigated breast cancer cell growth by inducing G1-phase cell cycle arrest and apoptosis. LINP1 also promoted breast cancer cell metastasis and influenced the expression of epithelial-mesenchymal transition-related markers. We identified p53 as a regulator of LINP1, and LINP1 overexpression could restore the metastatic effects of p53. Furthermore, LINP1 was upregulated in doxorubicin- and 5-fluorouracil-resistant cells and induced chemoresistance. We also observed that LINP1 enrichment played a critical functional role in chemoresistance by inhibiting chemotherapeutics-induced apoptosis. Moreover, LINP1 in tumors was associated with lower overall survival and disease-free survival. |
| Pubmed ID | 29293402 |
| Year | 2018 |
| Title | Long noncoding RNA LINP1 acts as an oncogene and promotes chemoresistance in breast cancer. |
| External Links |
| Links for LINP1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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