Detail
| LncRNA Name | LINP1 |
| Synonyms | NA |
| Region | GRCh38_10:6737382-6739026 Sequence |
| Ensembl | ENSG00000223784 |
| RefSeq | NR_138480 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Western blot, Northern blot, RIP, RNA pull-down assay etc. |
| Sample | cell lines (MDA-MB-231, MDA-MB-468, MCF7, HCT116 WT and HCT116 TP53) |
| Expression Pattern | up-regulated |
| Function Description | LINP1, which is overexpressed in human triple-negative breast cancer. We found that LINP1 enhances repair of DNA double-strand breaks by serving as a scaffold linking Ku80 and DNA-PKcs, thereby coordinating the NHEJ pathway. Importantly, blocking LINP1, which is regulated by p53 and epidermal growth factor receptor (EGFR) signaling, increases the sensitivity of the tumor-cell response to radiotherapy in breast cancer. |
| Pubmed ID | 27111890 |
| Year | 2016 |
| Title | Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. |
| External Links |
| Links for LINP1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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