Detail
| LncRNA Name | lnc34a |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | cell lines (Colo205, SW480, HT29, SW620, LS174T, DLD1 etc.) |
| Expression Pattern | up-regulated |
| Function Description | Here we report a novel LncRNA, Lnc34a, that is enriched in colon cancer stem cells (CCSCs) and initiates asymmetric division by directly targeting the microRNA miR-34a to cause its spatial imbalance. Lnc34a recruits Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously, hence epigenetically silencing miR-34a expression independent of its upstream regulator, p53. Lnc34a levels affect CCSC self-renewal and colorectal cancer (CRC) growth in xenograft models. Lnc34a is upregulated in late-stage CRCs, contributing to epigenetic miR-34a silencing and CRC proliferation. |
| Pubmed ID | 27077950 |
| Year | 2016 |
| Title | A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division |
| External Links |
| Links for lnc34a | GenBank HGNC lncrnadb Noncode |
| Links for colon cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.