Detail
| LncRNA Name | lncAGER |
| Synonyms | AGER-1 |
| Region | GRCh38_6:32180968-32184324 Sequence |
| Ensembl | ENSG00000204305 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, western blotting, Luciferase reporter assay |
| Sample | lung cancer tissues, lung cancer cell lines (PC9, L78, A549, GLC-82, SBC-5, 95D, NCI-H460, NCI-H292 and NCI- H1395) |
| Expression Pattern | down-regulated |
| Function Description | LncAGER expression was moderately correlated with AGER expression underlying a mechanism that lncAGER upregulates AGER by competitively binding to miRNA-185. LncAGER was significantly down-regulated in 76.4% of lung cancer tissues compared to adjacent normal tissues due to promoter hypermethylation. Over-expression of the lncRNA resulted in significant decreases in proliferation rate, migration ability,colony formation efficiency of lung cancer cells and tumor growth in nude mice. |
| Pubmed ID | 29068471 |
| Year | 2017 |
| Title | Long non-coding RNA AGER-1 functionally upregulates the innate immunity gene AGER and approximates its anti-tumor effect in lung cancer. |
| External Links |
| Links for lncAGER | GenBank HGNC lncrnadb Noncode |
| Links for lung cancer | Omim Cosmic |
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