Detail
| LncRNA Name | lncFOXO1 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | microarray, qPCR, Western blot, ChIP, CCK-8 assay etc. |
| Sample | breast cancer tissues, cell lines (MCF-7, BT-549, MB-231, MB-453 and MB-415) |
| Expression Pattern | down-regulated |
| Function Description | lncFOXO1 is significantly decreased in breast cancer tissues and cell lines and downregulation of lncFOXO1 expression associates with poorer overall survival. Functional assays demonstrated its suppressive role in breast cancer in vivo and in vitro. Mechanistically, lncFOXO1 suppressed the growth of breast cancer by increasing FOXO1 transcription. Moreover, we found that lncFOXO1 associated with BRCA-1-associated protein 1 (BAP1) and regulates its binding and the level of mono-ubiquitinated H2A at K119 (ubH2AK119) at FOXO1 promoter. |
| Pubmed ID | 28339037 |
| Year | 2017 |
| Title | The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1. |
| External Links |
| Links for lncFOXO1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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