Detail
| LncRNA Name | lnc-GNAT1-1 |
| Synonyms | NA |
| Region | GRCh38_3:50191612-50196516 Sequence |
| Ensembl | ENSG00000114349 |
| RefSeq | NA |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | CRC tissues, cell lines (SW480, SW620, HT29, LoVo, HCT116, and RKO) |
| Expression Pattern | down-regulated |
| Function Description | Expression of lnc-GNAT1-1 was decreased in liver metastasis than the primary tumor, while the later one is lower than the paired normal mucosa. Decreased lnc-GNAT1-1 expression was associated unfavorable clinicopathological features and a poor prognosis of CRC patients. Overexpression of lnc-GNAT1-1 could suppress the liver metastasis of CRC cells. Finally, we explored the underlying mechanism of the role lnc-GNAT1-1 plays in CRC, and found a positive correlation between lnc-GNAT1-1 and Raf kinase inhibitor protein (RKIP) expression both in cells and in patients' tissues. |
| Pubmed ID | 27912775 |
| Year | 2016 |
| Title | A novel long non-coding RNA lnc-GNAT1-1 is low expressed in colorectal cancer and acts as a tumor suppressor through regulating RKIP-NF-kB-Snail circuit. |
| External Links |
| Links for lnc-GNAT1-1 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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