Detail
| LncRNA Name | lnc-HOST2 |
| Synonyms | CERNA2, HOST2, lncRNA-HOST2, CERNA2 |
| Region | NA Sequence |
| Ensembl | |
| RefSeq | NR_134505 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qRT-PCR, Western blot |
| Sample | osteosarcoma tissues, cell lines (U2OS, MG-63, and KHOS) |
| Expression Pattern | up-regulated |
| Function Description | The expression levels of lnc-HOST2 in osteosarcoma tissues were significantly higher than those in corresponding noncancerous bone tissues (p < 0.01). Statistical assay indicated that the expression level of lnc-HOST2 was positively correlated with tumor stage (p = 0.003) and distant metastasis (p = 0.000).down-regulation of lnc-HOST2 suppressed proliferation and induced cell apoptosis in osteosarcoma cells. Notably, we confirmed that up-regulation of lnc-HOST2 led to Bcl-2 downregulation and Bax upregulation in osteosarcoma cells. |
| Pubmed ID | 29509239 |
| Year | 2018 |
| Title | Prognostic value of long non-coding RNA HOST2 expression and its tumor-promotive function in human osteosarcoma. |
| External Links |
| Links for lnc-HOST2 | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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