Detail
| LncRNA Name | Lnc-IL7R |
| Synonyms | NA |
| Region | GRCh38_5:35852695-35879603 Sequence |
| Ensembl | ENSG00000168685 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | cervical intraepithelial neoplasia |
| ICD-0-3 | M8077/2 |
| Methods | qPCR, Western blot, RNAi etc. |
| Sample | cervical intraepithelial neoplasia tissues, cell lines (Hela and SiHa) |
| Expression Pattern | up-regulated |
| Function Description | We here investigated the clinical role of inflammation-related LncRNA-IL7R (Lnc-IL7R) in healthy cervical tissue (n=15), CIN 1/2/3 (n=35), cervical cancer (n=70), and clarified its function via knockdown in vitro and in vivo. The results showed that the expression of Lnc-IL7R was increased from normal tissues to neoplastic lesions and cervical cancer. Patients with high expression of Lnc-IL7R had poor prognosis with short overall survival time, and cox regression analysis revealed that Lnc-IL7R could be independent prognostic factor for cervical cancer. These data indicated that Lnc-IL7R predicts a poor clinical outcome of cervical cancer patients, and knockdown of Lnc-IL7R is amenable to the treatment of cervical cancer. |
| Pubmed ID | 29720427 |
| Year | 2018 |
| Title | Up-regulation of inflammation-related LncRNA-IL7R predicts poor clinical outcome of patients with cervical cancer. |
| External Links |
| Links for Lnc-IL7R | GenBank HGNC lncrnadb Noncode |
| Links for cervical intraepithelial neoplasia | Omim Cosmic |
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