Detail
| LncRNA Name | lnc-OC1 |
| Synonyms | FRP, FSL1, OCC1, OCC-1, tsc36, MIR198 |
| Region | GRCh38_3:120392293-120451253 Sequence |
| Ensembl | ENSG00000163430 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, luciferase report assay, Western blot, in vitro knockdown |
| Sample | cell line (HEY-T30, SKOV4), bladder cancer |
| Expression Pattern | up-regulated |
| Function Description | Lnc-OC1 expression was associated with poor prognosis of OC patients.knockdown of Lnc-OC1 suppressed cell proliferation, colony formation, invasion and migration in vitro and inhibited tumorigenicity in vivo.lnc-OC1 repressed the expression of endogenous miR-34a and miR-34c as a sponge andvice versa. Moreover, rescue experiments demonstrated that the oncogenic function of Lnc-OC1 at leastpartially depended on suppressing miR-34a and miR-34c. |
| Pubmed ID | 29576507 |
| Year | 2018 |
| Title | A novel lncRNA, Lnc-OC1, promotes ovarian cancer cell proliferation and migration by sponging miR-34a and miR-35c. |
| External Links |
| Links for lnc-OC1 | GenBank HGNC lncrnadb Noncode |
| Links for ovarian cancer | Omim Cosmic |
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