Detail
| LncRNA Name | lnc-PCTST |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qRT-PCR, Western blot assay, ect. |
| Sample | The normal human pancreatic ductal cell line (hTERT-HPNE), Human pancreatic cancer cell lines (PANC-1, MiaPaCa-2, BxPC-3 and AsPC-1) and 293T cells, PC and non-tumor tissues |
| Expression Pattern | down-regulated |
| Function Description | lnc-PCTST expression is down-regulated in pancreatic cancer tissues. Also, lnc-PCTST has shown to be negatively correlated with transforming acidic coiled-coil 3 (TACC-3) expression.lnc-PCTST overexpression in pancreatic cancer cell lines inhibited cell proliferation and invasion in vitro, and tumorigenesis in vivo, but did not altered cell migration. Additionally, TACC-3 knockdown simulated the inhibiting effect of lnc-PCTST overexpression on pancreatic cancer cell lines, and the impaired proliferation, invasion effect and E-cadherin, vimentin expression on lnc-PCTST over-expressed cell lines can be rescued by overexpressed TACC-3. Significantly, the expression of lnc-PCTST was closely associated with its genomic neighboring gene TACC-3 and inhibited its promoter activity. |
| Pubmed ID | 29978472 |
| Year | 2018 |
| Title | Long non-coding RNA lnc-PCTST predicts prognosis through inhibiting progression of pancreatic cancer by downregulation of TACC-3. |
| External Links |
| Links for lnc-PCTST | GenBank HGNC lncrnadb Noncode |
| Links for pancreatic cancer | Omim Cosmic |
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