Detail
| LncRNA Name | lncRNA-AF147447 |
| Synonyms | AC009084.3 |
| Region | GRCh38_16:66944660-66945096 Sequence |
| Ensembl | ENSG00000280416 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | microarray, qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | gastric cancer tissues, cell lines (7901 and MKN45) |
| Expression Pattern | down-regulated |
| Function Description | We identified an lncRNA-AF147447 decreased expressed by H. pylori infection, which can inhibit GC proliferation and invasion in vitro and in vivo, act as a tumor suppressor in the development of H. pylori induced GC. LncRNA AF147447 could repress MUC2 expression by direct binding or increasing miR-34c expression. We also found that transcription factor E2F1 could be recruited to lncRNA AF147447 promoter by RNA immunoprecipatation and RNA pull down assays. |
| Pubmed ID | 27835575 |
| Year | 2016 |
| Title | Helicobacter pylori infection related long noncoding RNA (lncRNA) AF147447 inhibits gastric cancer proliferation and invasion by targeting MUC2 and up-regulating miR-34c. |
| External Links |
| Links for lncRNA-AF147447 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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