Detail
| LncRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | bladder cancer cell line T24 |
| Expression Pattern | up-regulated |
| Function Description | lncRNA-ATB was a molecular sponge of miR-126,and exerted tumor promoting effects by down-regulation of miR-126. Moreover, KRAS was a direct target of miR-126, and negatively regulated by miR-126. Finally, overexpression of KRAS increased cell viability, migration and invasion, as well as activated PI3K/AKT and mTOR signal pathways in T24 cells. |
| Pubmed ID | 29321082 |
| Year | 2018 |
| Title | Long noncoding RNA ATB promotes proliferation, migration and invasion in bladder cancer by suppressing microRNA-126. |
| External Links |
| Links for lncRNA-ATB | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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