Detail
| LncRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | microarray, qPCR, Western blot, Luciferase reporter assay, MTT assay etc. |
| Sample | cell line (SKBR-3) |
| Expression Pattern | up-regulated |
| Function Description | We identified long noncoding RNA activated by TGF-B (lnc-ATB) was the most remarkably upregulated lncRNA in TR SKBR-3 cells and the tissues of TR breast cancer patients. We found that lnc-ATB could promote trastuzumab resistance and invasion-metastasis cascade in breast cancer by competitively biding miR-200c, up-regulating ZEB1 and ZNF-217, and then inducing EMT. In addition, we also found that the high level of lnc-ATB was correlated with trastuzumab resistance of breast cancer patients. |
| Pubmed ID | 25871474 |
| Year | 2015 |
| Title | LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer. |
| External Links |
| Links for lncRNA-ATB | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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