Detail
| LncRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | microarray, qPCR etc. |
| Sample | HCC tissues, cell lines (SMMC-7721) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we observed that the lncRNA-activated by TGFB1 (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB upregulated ZEB1 and ZEB2 by competitively binding the miR-200 family and then induced EMT and invasion. In addition, lncRNA-ATB promoted organ colonization of disseminated tumor cells by binding IL-11 mRNA, autocrine induction of IL-11, and triggering STAT3 signaling. |
| Pubmed ID | 24768205 |
| Year | 2014 |
| Title | A long noncoding RNA activated by TGFB1-promotes the invasion-metastasis cascade in hepatocellular carcinoma. |
| External Links |
| Links for lncRNA-ATB | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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