Detail
| LncRNA Name | LncRNA-BX111 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, ChIP, RIP, Luciferase reporter assays, etc. |
| Sample | normal human pancreatic cell line (HPDE). four pancreatic cancer cell lines (SW1990, PANC-1, BxPC-3, AsPC1). noncancerous pancreatic (NP) and pancreatic cancer (PC) tissues, |
| Expression Pattern | up-regulated |
| Function Description | Taken together, our findings implicate a hypoxia-induced lncRNA contributes to metastasis and progression of pancreatic cancer, and suggest BX111 might be applied as a potential biomarker and therapeutic target for pancreatic cancer. Results also suggested that ZEB-1 and other regulators of EMT may maintain drug resistance in human PC cells.The clinical samples of pancreatic cancer further confirmed a positive association between BX111 and ZEB1. Moreover, high BX111 expression was correlated with late TNM stage, lymphatic invasion and distant metastasis, as well as short overall survival time in patients. |
| Pubmed ID | 29970904 |
| Year | 2018 |
| Title | Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription. |
| External Links |
| Links for LncRNA-BX111 | GenBank HGNC lncrnadb Noncode |
| Links for pancreatic cancer | Omim Cosmic |
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