Detail
| LncRNA Name | lncRNA-CIR |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, in vitro knockdown |
| Sample | 52 cancerous tissues and bladder cancer cell lines(T24, SW780, UBC-40, 5637 and UM-UC-3 ) |
| Expression Pattern | up-regulated |
| Function Description | upregulating lncRNA-CIR was demonstrated to promote viability and invasion in T24 and SW780 cells, whereas siRNA-mediated lncRNA-CIR-knockdown consistently exhibited the opposite effects. High lncRNA-CIR levels also dictated poor overall survival among patients with bladder cancer. Furthermore, in vivo implantation experiments also supported a tumorigenic function for lncRNA-CIR, as decreasing lncRNA-CIR levels markedly attenuated Ki-67 staining and xenograft tumor growt |
| Pubmed ID | 29435036 |
| Year | 2017 |
| Title | Long non-coding RNA cartilage injury-related promotes malignancy in bladder cancer. |
| External Links |
| Links for lncRNA-CIR | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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