Detail
| LncRNA Name | lncRNA-CLMAT3 |
| Synonyms | CTB-113P19.1, CLMAT3, SPARC-AS1 |
| Region | GRCh38_5:151676945-151724782 Sequence |
| Ensembl | ENSG00000249035 |
| RefSeq | NR_109873 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, Immunoprecipitation etc. |
| Sample | cell lines (HT-29, SW480, SW620, HCT116, LOVO, and CCC-HIE-2) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we demonstrate that lncRNA-CLMAT3 expression was significantly increased in colorectal cancer cells compared with a normal intestinal mucous cell line and that inhibition of lncRNA-CLMAT3 suppressed colorectal cancer cell proliferation in vitro. We also found that this reduced colorectal cancer cell proliferation due to lncRNA-CLMAT3 knockdown is associated with G0/G1 cell-cycle arrest induction and apoptosis enhancement. Furthermore, lncRNA-CLMAT3 knockdown enhanced Cdh1 expression and resulted in p27Kip accumulation via increased Skp2 protein ubiquitination. |
| Pubmed ID | 27391344 |
| Year | 2016 |
| Title | Downregulated long non-coding RNA CLMAT3 promotes the proliferation of colorectal cancer cells by targeting regulators of the cell cycle pathway. |
| External Links |
| Links for lncRNA-CLMAT3 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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