Detail
| LncRNA Name | lncRNA-LET |
| Synonyms | NPTN-IT1, lncRNA-LET |
| Region | GRCh38_15:73567012-73569294 Sequence |
| Ensembl | ENSG00000281183 |
| RefSeq | NR_103844 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, RIP, in vitro knockdown etc. |
| Sample | CRC tissues, cell lines (QSG-7701, LO2, SMMC-7721 etc.) |
| Expression Pattern | down-regulated |
| Function Description | Aberrant Expression of lncRNA-LET in Tumor Tissue. We found that the lncRNA-LET was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas. hypoxia-induced histone deacetylase 3 repressed lncRNA-LET by reducing the histone acetylation-mediated modulation of the lncRNA-LET promoter region. The downregulation of lncRNA-LET was found to be a key step in the stabilization of nuclear factor 90 protein, which leads to hypoxia-induced cancer cell invasion. |
| Pubmed ID | 23395002 |
| Year | 2013 |
| Title | Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. |
| External Links |
| Links for lncRNA-LET | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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