Detail
| LncRNA Name | lncRNA-LET |
| Synonyms | NPTN-IT1, lncRNA-LET |
| Region | GRCh38_15:73567012-73569294 Sequence |
| Ensembl | ENSG00000281183 |
| RefSeq | NR_103844 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | esophageal squamous cell cancer |
| ICD-0-3 | |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | esophageal squamous cell carcinoma tissues, cell lines (Het-1A,KYSE30,TE-1, KYSE150, KYSE410, and Eca-109) |
| Expression Pattern | up-regulated |
| Function Description | Down-regulated lncRNA-LET also indicated poor overall survival of ESCC patients.lncRNA-LET inhibits the proliferation and migration of ESCC cells, and the effects of miR-548k on ESCC are dependent on the negative regulation of lncRNA-LET. |
| Pubmed ID | 29126868 |
| Year | 2017 |
| Title | Up-regulated miR-548k promotes esophageal squamous cell carcinoma progression via targeting long noncoding RNA-LET. |
| External Links |
| Links for lncRNA-LET | GenBank HGNC lncrnadb Noncode |
| Links for esophageal squamous cell cancer | Omim Cosmic |
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