Detail
| LncRNA Name | lncRNAâ??MIF |
| Synonyms | GIF, GLIF |
| Region | GRCh38_22:23894004-23895227 Sequence |
| Ensembl | ENSG00000240972 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | cell line (HCT116) |
| Expression Pattern | differential expression |
| Function Description | In this study, we demonstrate that lncRNAâ??MIF (Myc inhibitory factor), which is transcribed by câ??Myc, is able to reduce câ??Myc expression. Mechanistically, lncRNAâ??MIF competes with coding mRNA Fbxw7 for miRâ??586 and relieves the inhibitory effect of miRâ??586 on Fbxw7, thereby leading to increased Fbxw10 expression and decreased c-Myc level. |
| Pubmed ID | 27317567 |
| Year | 2016 |
| Title | LncRNA-MIF, a c-Myc-activated long non-coding RNA, suppresses glycolysis by promoting Fbxw10-mediated c-Myc degradation |
| External Links |
| Links for lncRNAâ??MIF | GenBank HGNC lncrnadb Noncode |
| Links for colon cancer | Omim Cosmic |
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