Here, we identified LncRNA-ENST00000460407 and concluded that it functioned as a tumor suppressor as well as a potential diagnostic or prognostic marker in RCC. This LncRNA could directly bind to AR and post-transcriptionally suppress AR protein and transactivation to regulate signals such as miR-143-3p/AKT/MMP-13/K-RAS/P-ERK to influence RCC cell invasion, migration and proliferation.Significantly, we find that Sunitinib induces LncRNASARCC expression, and the level of LncRNA-SARCC determines the sensitivity to this drug.The vast majority of patients with mRCC have only a median of 13 months survival time.