Detail
| LncRNA Name | lncRNA-SRLR |
| Synonyms | LNCSRLR, lncRNA-SRLR |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | microarray, RIP, ChIP, RNA pull-down assay etc. |
| Sample | RCC tissues, cell lines (786-O, ACHN, 769P, HEK-293T, Caki-2 etc.) |
| Expression Pattern | up-regulated |
| Function Description | Herein, we identified a long non-coding RNA referred to as lncRNA-SRLR (sorafenib resistance-associated lncRNA in RCC) that is upregulated in intrinsically sorafenib-resistant RCCs. lncRNA-SRLR knockdown sensitized nonresponsive RCC cells to sorafenib treatment, whereas the overexpression of lncRNA-SRLR conferred sorafenib resistance to responsive RCC cells. Mechanistically, lncRNA-SRLR directly binds to NF-kB and promotes IL-6 transcription, leading to the activation of STAT3 and the development of sorafenib tolerance. A STAT3 inhibitor and IL-6-receptor antagonist both restored the response to sorafenib treatment. |
| Pubmed ID | 27841868 |
| Year | 2016 |
| Title | Long noncoding RNA-SRLR elicits intrinsic sorafenib resistance via evoking IL-6/STAT3 axis in renal cell carcinoma. |
| External Links |
| Links for lncRNA-SRLR | GenBank HGNC lncrnadb Noncode |
| Links for renal cell carcinoma | Omim Cosmic |
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