Detail
| LncRNA Name | lncRNA-TTN-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:178521183-178779963 Sequence |
| Ensembl | ENSG00000237298 |
| RefSeq | NR_038272 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | esophageal squamous cell cancer |
| ICD-0-3 | |
| Methods | Microarray, qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown, RNAi, RIP |
| Sample | ESCC tissue, ESCC cell lines (Eca-109, KYSE 30, KYSE 150, KYSE180, KYSE410, KYSE450, KYSE510, TE-10 and TE-13) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA-TTN-AS1 as an oncogene is highly expressed in ESCC tissues and cell lines, and promotes ESCC cell proliferation and metastasis. Mechanistically, lncRNA-TTN-AS1 promotes expression of transcription factor Snail1 by competitively binding miR-133b, resulting in the epithelial-mesenchymal transition (EMT) cascade.Moreover,lncRNA-TTN-AS1 also induces FSCN1 expression by sponging miR-133b and upregulation of mRNA-stabilizing protein HuR,which further promotes ESCC invasion cascades. |
| Pubmed ID | 29101304 |
| Year | 2017 |
| Title | Functional Role of a Novel Long Noncoding RNA TTN-AS1 in Esophageal Squamous Cell Carcinoma Progression and Metastasis. |
| External Links |
| Links for lncRNA-TTN-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for esophageal squamous cell cancer | Omim Cosmic |
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