Detail
| LncRNA Name | Lnc-THOR |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | osteosarcoma tissues, cell lines (U2OS, MG-63 and SaOs-2) |
| Expression Pattern | down-regulated |
| Function Description | In the current study, we show that Lnc-THOR is expressed in established and primary human OS cells. It is also detected in human OS tissues, but not in the surrounding normal bone tissues. siRNA-induced knockdown or CRSIPR/Cas9-mediated knockout Lnc-THOR significantly inhibited human OS cell survival and proliferation. Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) target mRNAs, including IGF2, GLI1 and CD44, were downregulated in Lnc-THOR-silenced OS cells as well. Conversely, forced over-expression of Lnc-THOR enhanced IGF2BP1 target mRNA expression, promoting OS cell survival and proliferation. In vivo, xenograft tumors of Lnc-THOR-knockout U2OS cells grew significantly slower than the control U2OS tumors. |
| Pubmed ID | 29626476 |
| Year | 2018 |
| Title | Long non-coding RNA THOR promotes human osteosarcoma cell growth in-vitro and in-vivo. |
| External Links |
| Links for Lnc-THOR | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.