Detail
| LncRNA Name | LOC344887 |
| Synonyms | NMRAL2P, NMRAL1P1 |
| Region | GRCh38_3:185959943-185980872 Sequence |
| Ensembl | ENSG00000171658 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, RNAi, Western blot, CCK-8 assay etc. |
| Sample | GBC tissues, cell lines (NOZ, H69, SGC-996) |
| Expression Pattern | up-regulated |
| Function Description | Loc344887 was upregulated significantly after ectopic expression of nuclear factor Nrf2 in GBC cells. Downregulation of Loc344887 in GBC cells suppressed cell proliferation, blocked cells in G0/S phase, and decreased the migration and invasion cell numbers. In addition, downregulation of Loc344887 decreased the expression of transcription factor Twist, mesenchymal marker Vimentin, and N-cadherin and increased the expression of epithelial maker E-cadherin, which could prompt a mesenchymal-to-epithelial transition phenotype. |
| Pubmed ID | 28245089 |
| Year | 2017 |
| Title | The NmrA-like family domain containing 1 pseudogene Loc344887 is amplified in gallbladder cancer and promotes epithelial-mesenchymal transition. |
| External Links |
| Links for LOC344887 | GenBank HGNC lncrnadb Noncode |
| Links for gallbladder cancer | Omim Cosmic |
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