Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name LOC553103
   Synonyms MIR3936HG, SLC22A5-AS1
   Region GRCh38_5:132311285-132369916    Sequence
   Ensembl ENSG00000233006
   RefSeq NR_110997
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name gastric cancer
   ICD-0-3 C16  
   Methods microarray, qPCR, RNAi, Luciferase reporter assay etc.
   Sample cell line (AGS)
   Expression Pattern up-regulated
   Function Description

We identified and validated that a novel long non-coding RNA (lncRNA) LOC553103 was downregulated by EBV-miR-BART6-3p, and LOC553103 knockdown by specific siRNAs phenocopied the effect of EBV-miR-BART6-3p, while LOC553103 overexpression promoted cancer cell migration and invasion to facilitate EMT.

   Pubmed ID 27584792
   Year 2016
   Title Epstein-Barr virus-encoded miR-BART6-3p inhibits cancer cell metastasis and invasion by targeting long non-coding RNA LOC553103.
   External Links
   Links for  LOC553103 GenBank       HGNC       lncrnadb       Noncode
   Links for  gastric cancer Omim       Cosmic

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