Detail
| LncRNA Name | LOC554202 |
| Synonyms | MIR31HG, hsa-lnc-31, LncHIFCAR, LOC554202 |
| Region | GRCh38_9:21455642-21559669 Sequence |
| Ensembl | ENSG00000171889 |
| RefSeq | NR_027054 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | chordoma |
| ICD-0-3 | C11.9 M9370/3 |
| Methods | qPCR, Luciferase reporter assay, Western blot, RIP |
| Sample | chordoma tissues, cell lines (U-CH1and JHC7) |
| Expression Pattern | up-regulated |
| Function Description | elevated expression of LOC554202 was associated with a decreased level of miR-31 in cancer tissues. Knockdown of LOC554202 or overexpression of miR-31 suppressed the proliferation, migration, and invasion of chordoma cells.EZH2 as a binding protein of LOC554202, and it was positively regulated by LOC554202, leading to the reduced expression of miR-31.the impaired function of miR-31 restored expression of the oncogene RNF144B and maintained the metastasis-promoting activity in vitro.the anti-tumour effects of knockdown of LOC554202, which inhibited EZH2/miR-31 to activate the oncogene RNF144B. LOC554202 may play an important role in the progression of chordoma by the direct upregulation of EZH2 and indirect promotion of RNF144B via miR-31. |
| Pubmed ID | 28963737 |
| Year | 2017 |
| Title | long non-coding RNA LOC554202 modulates chordoma cell proliferation and invasion by recruiting EZH2 and regulating miR-31 expression. |
| External Links |
| Links for LOC554202 | GenBank HGNC lncrnadb Noncode |
| Links for chordoma | Omim Cosmic |
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