Detail
| LncRNA Name | LOC554202 |
| Synonyms | MIR31HG, hsa-lnc-31, LncHIFCAR, LOC554202 |
| Region | GRCh38_9:21455642-21559669 Sequence |
| Ensembl | ENSG00000171889 |
| RefSeq | NR_027054 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 M8500/3 |
| Methods | qPCR, RNAi, Western blot, RIP, Dual-luciferase reporter assay, ISH etc. |
| Sample | cell lines (AsPC-1, PANC-1, CFPAC-1, Hs 766T, SW 1990, MIA PaCa-2, and BxPC-3) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we discovered that lncRNA MIR31HG is markedly upregulated in PDAC. Knockdown of MIR31HG significantly suppressed PDAC cell growth, induced apoptosis and G1/S arrest, and inhibited invasion, whereas enhanced expression of MIR31HG had the opposite effects. Inhibition of miR-193b expression significantly upregulated the MIR31HG level, while overexpression of miR-193b suppressed MIR31HG's expression and function, suggesting that MIR31HG is negatively regulated by miR-193b. |
| Pubmed ID | 26549028 |
| Year | 2016 |
| Title | Long noncoding RNA MIR31HG exhibits oncogenic property in pancreatic ductal adenocarcinoma and is negatively regulated by miR-193b. |
| External Links |
| Links for LOC554202 | GenBank HGNC lncrnadb Noncode |
| Links for pancreatic ductal adenocarcinoma | Omim Cosmic |
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