Detail
| LncRNA Name | LSINCT5 |
| Synonyms | NA |
| Region | GRCh38_5:2712591-2715237 Sequence |
| Ensembl | NA |
| RefSeq | NR_145480 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Northern blot etc. |
| Sample | cell lines (HMEC, MCF7, MDA157 etc.) |
| Expression Pattern | up-regulated |
| Function Description | LSINCT5 is overexpressed in breast and ovarian cancer cell lines and tumor tissues, relative to their normal counterpart. In addition, knocking down the expression of LSINCT5 in cancer-derived cell lines causes a decrease in cellular proliferation. Two genes that were significantly downregulated were the lncRNA NEAT-1 and a protein coding gene PSPC1. We have therefore characterized a novel lncRNA that is overexpressed in breast and ovarian cancers, enhances cellular proliferation and may play a significant role in multiple processes. |
| Pubmed ID | 21532345 |
| Year | 2011 |
| Title | LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation. |
| External Links |
| Links for LSINCT5 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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