Detail
| LncRNA Name | LUCAT1 |
| Synonyms | LUCAT1, SCAL1 |
| Region | GRCh38_5:91303029-91314402 Sequence |
| Ensembl | ENSG00000248323 |
| RefSeq | NR_103548 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | esophageal squamous cell cancer |
| ICD-0-3 | |
| Methods | qPCR, Western blot, RIP, in vitro knockdown etc. |
| Sample | cell lines (KYSE-30, TE-2, HCE-4, HCE-7), ESCC tissues |
| Expression Pattern | up-regulated |
| Function Description | LUCAT1 knockdown reduced cell proliferation,induced apoptosis,and upregulated tumor-suppressor genes by reducing DNA methylation in KYSE-30-cells. Moreover,LUCAT1 siRNA reduced DNA methyltransferase 1 (DNMT1) protein levels without affecting transcription. LUCAT1 regulates the stability of DNMT1 and inhibits the expression of tumor suppressors through DNA methylation, leading to the formation and metastasis of ESCC. |
| Pubmed ID | 29247823 |
| Year | 2018 |
| Title | The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma. |
| External Links |
| Links for LUCAT1 | GenBank HGNC lncrnadb Noncode |
| Links for esophageal squamous cell cancer | Omim Cosmic |
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