Detail
| LncRNA Name | LUCAT1 |
| Synonyms | LUCAT1, SCAL1 |
| Region | GRCh38_5:91303029-91314402 Sequence |
| Ensembl | ENSG00000248323 |
| RefSeq | NR_103548 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 M8005/0 |
| Methods | qPCR, Western blot, Luciferase activity assay, etc. |
| Sample | ccRCC tissues, cell lines (786-O, Caki-1, ACHN, HK-2) |
| Expression Pattern | up-regulated |
| Function Description | Upregulated LUCAT1 was positively correlated with larger tumor size, advanced tumor-node-metastasis (TNM) stage, higher smoking frequency, nodal metastasis and shorter overall survival in patients with ccRCC. We then found that LUCAT1 directly bound and inhibited the expression of micoRNA-495-3p (miR-495-3p), which subsequently regulated the expression of special adenine-thymine (AT)-rich DNA-binding protein 1 (SATB1). |
| Pubmed ID | 29932248 |
| Year | 2018 |
| Title | Long noncoding RNA lung cancer associated transcript 1 promotes proliferation and invasion of clear cell renal cell carcinoma cells by negatively regulating miR-495-3p. |
| External Links |
| Links for LUCAT1 | GenBank HGNC lncrnadb Noncode |
| Links for clear cell renal cell carcinoma | Omim Cosmic |
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