Detail
| LncRNA Name | MAGI2-AS3 |
| Synonyms | ENST00000414797 |
| Region | GRCh38_7:79452877-79471208 Sequence |
| Ensembl | ENSG00000234456 |
| RefSeq | NR_038343 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot etc. |
| Sample | breast cancer tissues, cell lines (MDA-MB-231, MCF-7 and MCF-10A) |
| Expression Pattern | down-regulated |
| Function Description | Our results showed MAGI2-AS3 to be down-regulated in breast cancer tissues compared to normal adjacent tissues. Moreover, MAGI2-AS3 markedly inhibited breast cancer cell growth and increased expression of Fas and Fas ligand (FasL). In conclusion, our data suggest that MAGI2-AS3 expression is decreased in breast cancer and that MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. |
| Pubmed ID | 29679339 |
| Year | 2018 |
| Title | Long non-coding RNA (lncRNA) MAGI2-AS3 inhibits breast cancer cell growth by targeting the Fas/FasL signalling pathway. |
| External Links |
| Links for MAGI2-AS3 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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