Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | choriocarcinoma |
| ICD-0-3 | M9220/3 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | choriocarcinoma cell line (HT cells) |
| Expression Pattern | up-regulated |
| Function Description | Being specifically upregulated in choriocarcinoma cell lines, the under-researched lncRNA-MALAT1 promoted choriocarcinoma cell growth by targeting miR-218. After MALAT1 knockdown,proliferation of human choriocarcinoma cell in vitro was dramatically hindered,and the tumor size in vivo was reducedã??miR-218-mediated Fbxw8 regulation was required for MALAT1-induced choriocarcinoma cell proliferation.Taken together, MALAT1 might promote choriocarcinoma tumor growth through miR-218-mediated Fbxw8 regulation.MALAT1 might be an oncogenic lncRNA that promoted choriocarcinoma proliferation and could be therapeutically targeted in human choriocarcinoma.A higher expression of MALAT1 predicts a poorer prognosis, including a shorter overall survival, in patients with cervical cancer. |
| Pubmed ID | 29096355 |
| Year | 2017 |
| Title | The long non-coding RNA MALAT1 interacted with miR-218 modulates choriocarcinoma growth by targeting Fbxw8 |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for choriocarcinoma | Omim Cosmic |
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