Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | diffuse large B-cell lymphoma |
| ICD-0-3 | M9680/3 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay etc. |
| Sample | cell lines (IM-9I, Farage, Pfeiffer, Raji, Daud, Ly1, Ly3, Ly8, and Ly10) |
| Expression Pattern | up-regulated |
| Function Description | The expression of lncRNA MALAT-1 in each DLBCL cell line was higher than in the IM-9 cells, with the Farage cells ranking highest. When compared with the blank and the siNC groups, the siRNA-MALAT-1 group showed a decreased cell survival rate, an increased percentage of cells in G0/G1 phase, a decreased proportion of cells in S and G2/M phases, and a reduced number of migratory cell at each time point. When compared with the blank and the siNC groups, the formation of autophagosomes, increased LC3-II/LC3-I expression, decreased p62 expression, and increased expression of the autophagy gene ATG5 were observed in the siRNA-MALAT-1 group at each time point. |
| Pubmed ID | 28292022 |
| Year | 2017 |
| Title | The effects of the long non-coding RNA MALAT-1 regulated autophagy-related signaling pathway on chemotherapy resistance in diffuse large B-cell lymphoma. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for diffuse large B-cell lymphoma | Omim Cosmic |
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